RoboCrook Rick and Nick ICK Carmine the Cat Dr. Belljar Medeva Judge R. B. Traitor Hannah Lulu Rip Shipoff I. I. Captain Buckle N. Bronco Baron Grinnit Baron Wasteland General Mayhem Patty Lacerny Eartha Brute Wonder Rat Sir Vile Contessa Jaqueline Hyde Vic the Slick Double Trouble Kneemoi Top Grunge
Carmen Sandiego is a thieving villain that allied with Mike J. Fined in the House of Animals franchise. She often tried to kill our main heroes (Russell and Zoe), but failed. She leads an army of V.H.O.T.S.B.T.E. members known as V.I.L.E., the Villains International League of Evil.